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Article

The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled.

Development (Cambridge, England) - 22 May 2020

Kratzer Marie-Claire, Becker Sarah F S, Grund Anita, Merks Anne, Harnoš Jakub, Bryja Vítězslav, Giehl Klaudia, Kashef Jubin, Borchers Annette

Abstract excerpt

Directional migration during embryogenesis and tumor progression faces the challenge that numerous external signals need to converge to precisely control cell movement. The Rho guanine exchange factor (GEF) Trio is especially well suited to relay signals, as it features distinct catalytic domains to activate Rho GTPases. Here, we show that Trio is required for Xenopus cranial neural crest (NC) cell migration and...

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Identifiers

PMID: 32366678
DOI: 10.1242/dev.186338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled.PMID 32366678Read ↗

Trio cooperates with Myh9 to regulate neural crest-derived craniofacial development.Semantic proximity Read ↗

Control of dendritic morphogenesis by Trio in Drosophila melanogaster.Semantic proximity Read ↗

Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding.Semantic proximity Read ↗

The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth.Semantic proximity Read ↗

Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos.Semantic proximity Read ↗

The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain.Semantic proximity Read ↗

Rac function and regulation during Drosophila development.Semantic proximity Read ↗

Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant.Semantic proximity Read ↗

The Abl pathway bifurcates to balance Enabled and Rac signaling in axon patterning in Drosophila.Semantic proximity Read ↗

Genetic variants linked to neurodevelopmental disorders within the β3-β4 loop of the TRIO PH2 domain release autoinhibition of GEF2 activitySemantic proximity Read ↗

Molecular separation of two signaling pathways for the receptor, Notch.Semantic proximity Read ↗

Opposite Modulation of RAC1 by Mutations in TRIO Is Associated with Distinct, Domain-Specific Neurodevelopmental Disorders.Semantic proximity Read ↗

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