Transcription factor IIB acetylates itself to regulate transcription.

Abstract excerpt

Acetylation is a well-known regulatory post-translational modification, but a biological function for acetylation in regulating basal transcription factors has not been reported. Here we show that the general transcription factor TFIIB, which is required for the initiation of eukaryotic polymerase II transcription, is acetylated. TFIIB is also an autoacetyltransferase, although it shares no sequence homology with...

Topics

• Acetyl Coenzyme A
• Acetylation
• Acetyltransferases
• Amino Acid Sequence
• Gene Expression Regulation
• HeLa Cells
• Humans
• Kinetics
• Molecular Sequence Data
• Mutation
• Protein Binding
• Protein Structure, Tertiary