Targeted recruitment of Rpd3 histone deacetylase represses transcription by inhibiting recruitment of Swi/Snf, SAGA, and TATA binding protein.

doi:10.1128/MCB.22.18.6458-6470.2002

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Article

Targeted recruitment of Rpd3 histone deacetylase represses transcription by inhibiting recruitment of Swi/Snf, SAGA, and TATA binding protein.

Molecular and cellular biology - 1 Sept 2002

Deckert Jutta, Struhl Kevin

Abstract excerpt

Certain DNA-binding repressors inhibit transcription by recruiting Rpd3 histone deacetylase complexes to promoters and generating domains of histone deacetylation that extend over a limited number of nucleosomes. Here, we show that the degree of Rpd3-dependent repression depends on the activator and the level of activation, not the extent of histone deacetylation. In all cases tested, activator binding is...

Topics

Acetyltransferases
Alleles
Chromatin
DNA-Binding Proteins
Histone Acetyltransferases
Histone Deacetylases
Histones
Models, Genetic
Nuclear Proteins
Precipitin Tests
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Binding

Protein Kinases

Repressor Proteins

Saccharomyces cerevisiae Proteins

TATA-Box Binding Protein

Transcription Factors

Transcription, Genetic

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Identifiers

PMID: 12192044
DOI: 10.1128/MCB.22.18.6458-6470.2002
PMCID: PMC135627

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