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Article

Unexpected non-Hoogsteen-based mutagenicity mechanism of FaPy-DNA lesions.

Nature chemical biology - 1 Jul 2013

Gehrke Tim H, Lischke Ulrike, Gasteiger Karola L, Schneider Sabine, Arnold Simone, Müller Heiko C, Stephenson David S, Zipse Hendrik, Carell Thomas

Abstract excerpt

8-Oxopurines (8-oxodG and 8-oxodA) and formamidopyrimidines (FaPydG and FaPydA) are major oxidative DNA lesions involved in cancer development and aging. Their mutagenicity is believed to result from a conformational shift of the N9-C1' glycosidic bonds from anti to syn, which allows the lesions to form noncanonical Hoogsteen-type base pairs with incoming triphosphates during DNA replication. Here we present...

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PMID: 23685671
DOI: 10.1038/nchembio.1254

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