Article
Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter.
Molecular and cellular biology - 1 Apr 2002
Nakagawa Takahito, Takahashi Masato, Ozaki Toshinori, Watanabe Ki Ken-ichi, Todo Satoru, Mizuguchi Hiroyuki, Hayakawa Takao, Nakagawara Akira
Abstract excerpt
p73 is a p53-related tumor suppressor but is also induced by oncogene products such as E2F-1, raising a question as to whether p73 is a tumor suppressor gene or oncogene. Unlike p53, p73 has several variants, including Delta Np73, which lacks the NH(2)-terminal transactivation domain. Although, in developing neurons, Delta Np73 is expressed abundantly and seems to inhibit the proapoptotic function of p53, the...
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