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Article

Structure and apoptotic function of p73

28 Feb 2015

Abstract excerpt

p73 is a structural and functional homologue of the p53 tumor suppressor protein. Like p53, p73 induces apoptosis and cell cycle arrest and transactivates p53-responsive genes, conferring its tumor suppressive activity. In addition, p73 has unique roles in neuronal development and differentiation. The importance of p73-induced apoptosis lies in its capability to substitute the pro-apoptotic activity of p53 in...

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Identifiers

PMID: 25441426
DOI: 10.5483/bmbrep.2015.48.2.255

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