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Article

Mechanism of induction of apoptosis by p73 and its relevance to neuroblastoma biology.

Annals of the New York Academy of Sciences - 1 Dec 2004

Rossi Mario, Sayan A Emre, Terrinoni Alessandro, Melino Gerry, Knight Richard A

Abstract excerpt

TP73, as a TP53 homologue, drew the attention of tumor biologists because it is rarely mutated in human cancers and can induce cell cycle arrest and apoptosis by activating genes also regulated by p53. However, TP73 harbors an additional promoter that produces a dominant negative p73 protein (deltaNp73) having the opposite effect of the TAp73 protein. Thus, the regulation of p53 responsive genes in the absence of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15650240
DOI: 10.1196/annals.1322.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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