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Article

DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors.

The Journal of experimental medicine - 16 Sept 2002

Zaika Alex I, Slade Neda, Erster Susan H, Sansome Christine, Joseph Troy W, Pearl Michael, Chalas Eva, Moll Ute M

Abstract excerpt

p73 has significant homology to p53. However, tumor-associated up-regulation of p73 and genetic data from human tumors and p73-deficient mice exclude a classical Knudson-type tumor suppressor role. We report that the human TP73 gene generates an NH(2) terminally truncated isoform. DeltaNp73 derives from an alternative promoter in intron 3 and lacks the transactivation domain of full-length TAp73. DeltaNp73 is...

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Identifiers

PMID: 12235210
DOI: 10.1084/jem.20020179
PMCID: PMC2194062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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