Article
Mutations of the DRY motif that preserve beta 2-adrenoceptor coupling.
Receptors & channels - 1 Jan 1998
Seibold A, Dagarag M, Birnbaumer M
Abstract excerpt
The largest family of G protein coupled receptors is characterized by the presence of the DRY motif at the boundary between the third transmembrane region and the second intracellular loop. Inspection of a recent alignment containing 620 receptors reveals that arginine is the best conserved amino...
Topics
- Amino Acid Sequence
- Cell Line, Transformed
- GTP-Binding Proteins
- Humans
- Molecular Sequence Data
- Mutation
- Receptors, Adrenergic, beta-2
- Receptors, Vasopressin
- Sequence Alignment
- Signal Transduction