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Article

alpha 2-HS glycoprotein/fetuin, a transforming growth factor-beta/bone morphogenetic protein antagonist, regulates postnatal bone growth and remodeling.

The Journal of biological chemistry - 31 May 2002

Szweras Melanie, Liu Danmei, Partridge Emily A, Pawling Judy, Sukhu Balram, Clokie Cameron, Jahnen-Dechent Willi, Tenenbaum Howard C, Swallow Carol J, Grynpas Marc D, Dennis James W

Abstract excerpt

Soluble transforming growth factor-beta (TGF-beta)/bone morphogenetic protein (BMP)-binding proteins are widely distributed in mammalian tissues and control cytokine access to membrane signaling receptors. The serum and bone-resident glycoprotein alpha2-HS-glycoprotein/fetuin (ASHG) binds to TGF-beta/BMP cytokines and blocks TGF-beta1 binding to cell surface receptors. Therefore, we examined bone growth and...

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Identifiers

PMID: 11901155
DOI: 10.1074/jbc.M112234200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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