Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chondrocyte-specific knockout of the G protein G(s)alpha leads to epiphyseal and growth plate abnormalities and ectopic chondrocyte formation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2005

Sakamoto Akio, Chen Min, Kobayashi Tatsuya, Kronenberg Henry M, Weinstein Lee S

Abstract excerpt

UNLABELLED: G(s)alpha is a ubiquitously expressed G protein alpha-subunit that couples receptors to adenylyl cyclase. Mice with chondrocyte-specific ablation of the G(s)alpha gene had severe epiphyseal and growth plate abnormalities and ectopic cartilage formation within the metaphyseal region of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Bones
Share to Chondrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Lethal

Share to Growth Plate

Share to GTP-Binding Protein alpha Subunits, Gs

Share to Hedgehog Proteins

Share to Parathyroid Hormone-Related Protein

Share to Trans-Activators

Source

Identifiers

PMID: 15765186
DOI: 10.1359/JBMR.041210

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15765186-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chondrocyte-specific knockout of the G protein G(s)alpha leads to epiphyseal and growth plate abnormalities and ectopic chondrocyte formation.PMID 15765186Read ↗

Deficiency of the G-protein alpha-subunit G(s)alpha in osteoblasts leads to differential effects on trabecular and cortical bone.Semantic proximity Read ↗

The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C.Semantic proximity Read ↗

Overexpression of GαS in Murine Osteoblasts In Vivo Leads to Increased Bone Mass and Decreased Bone Quality.Semantic proximity Read ↗

Endocrine manifestations of stimulatory G protein alpha-subunit mutations and the role of genomic imprinting.Semantic proximity Read ↗

G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes.Semantic proximity Read ↗

Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification.Semantic proximity Read ↗

Heterozygous inactivation of <i>Gnas</i> in adipose-derived mesenchymal progenitor cells enhances osteoblast differentiation and promotes heterotopic ossificationSemantic proximity Read ↗

PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophySemantic proximity Read ↗

Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP.Semantic proximity Read ↗

Smad4 is required for the normal organization of the cartilage growth plate.Semantic proximity Read ↗

Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptor.Semantic proximity Read ↗

Expression of an active Gαs mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.