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CTLA-4 (+49A/G) Polymorphism in Type 1 Diabetes Children of Sudanese Population

15 Feb 2021

Abstract excerpt

Abstract Background Type 1 diabetes mellitus (T1DM) is an organ-specific T cell-mediated autoimmune disease, characterized by destruction of pancreatic islets. Cytotoxic lymphocyte antigen-4 (CTLA-4) is a negative regulator of T cell proliferation, thus conferring susceptibility to autoimmunity. Aims This study aimed to investigate the association of CTLA-4 +49A/G (rs231775) polymorphism with a risk of T1DM in...

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PMID: 33748819
DOI: 10.1055/s-0041-1723008

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CTLA-4 (+49A/G) Polymorphism in Type 1 Diabetes Children of Sudanese PopulationPMID 33748819Read ↗

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