Article
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry.
Human molecular genetics - 1 Jul 1996
Nisticò L, Buzzetti R, Pritchard L E, Van der Auwera B, Giovannini C, Bosi E, Larrad M T, Rios M S, Chow C C, Cockram C S, Jacobs K, Mijovic C, Bain S C, Barnett A H, Vandewalle C L, Schuit F, Gorus F K, Tosi R, Pozzilli P, Todd J A
Abstract excerpt
Susceptibility to autoimmune insulin-dependent (type 1) diabetes mellitus is determined by a combination of environmental and genetic factors, which include variation in MHC genes on chromosome 6p21 (IDDM1) and the insulin gene on chromosome 11p15 (IDDM2). However, linkage to IDDM1 and IDDM2 cannot explain the clustering of type 1 diabetes in families, and a role for other genes is inferred. In the present report...
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