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Article

Toll-like receptor 2 deficiency shifts PrP106-126-induced microglial activation from a neurotoxic to a neuroprotective phenotype.

Journal of molecular neuroscience : MN - 1 Apr 2015

Wang Jihong, Zhao Deming, Pan Bo, Fu Yongyao, Shi Fushan, Kouadir Mohammed, Yang Lifeng, Yin Xiaomin, Zhou Xiangmei

Abstract excerpt

Prion diseases are fatal neurodegenerative diseases characterized by spongiform change, neuronal loss, and gliosis involving microglial activation in the central nervous system. Microglial activation is thought to play a key role in the pathogenesis of prion disease; however, the molecular mechanisms underlying prion-induced microglial activation are not well understood. The present study underlines the...

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Source

Identifiers

PMID: 25330861
DOI: 10.1007/s12031-014-0442-0

Genes

TLR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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