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Article

A prion protein fragment primes type 1 astrocytes to proliferation signals from microglia.

Neurobiology of disease - 1 Apr 1998

Brown D R, Schmidt B, Kretzschmar H A

Abstract excerpt

Giliosis is a hallmark of prion disease. A neurotoxic prion peptide (PrP106-126) induces astrocyte proliferation in the presence of microglia. This peptide also directly enhances microglial proliferation in culture. We have investigated this further to understand the method by which factors released by microglia and PrP106-126 work together to enhance astrocyte proliferation. PrP106-126 in the presence of...

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Identifiers

PMID: 9666480
DOI: 10.1006/nbdi.1998.0169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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