A prion protein fragment primes type 1 astrocytes to proliferation signals from microglia.

doi:10.1006/nbdi.1998.0169

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A prion protein fragment primes type 1 astrocytes to proliferation signals from microglia.

Neurobiology of disease - 1 Apr 1998

Brown D R, Schmidt B, Kretzschmar H A

Abstract excerpt

Giliosis is a hallmark of prion disease. A neurotoxic prion peptide (PrP106-126) induces astrocyte proliferation in the presence of microglia. This peptide also directly enhances microglial proliferation in culture. We have investigated this further to understand the method by which factors relea...

Topics

Animals
Animals, Newborn
Astrocytes
Cell Communication
Cell Division
Cells, Cultured
Culture Media, Conditioned
Granulocyte-Macrophage Colony-Stimulating Factor
Interleukin-1
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Microglia
Mitogens
Oxidative Stress
Peptide Fragments
Phenotype
Prions

Source

Open in PubMed

Identifiers

PMID: 9666480
DOI: 10.1006/nbdi.1998.0169

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9666480-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics