Article
Allosteric effects potentiating the release of the second fibrinopeptide A from fibrinogen by thrombin.
The Journal of biological chemistry - 31 May 2002
Shainoff John R, Smejkal Gary B, DiBello Patricia M, Sung Shen-Shu, Bush Leslie A, Di Cera Enrico
Abstract excerpt
Fibrin formation depends on the release of the two N-terminal fibrinopeptides A (FPA) from fibrinogen, and its formation is accompanied by an intermediate, alpha-profibrin, which lacks only one of the FPA. In this study, we confirm that the maximal levels of alpha-profibrin found over the course of thrombin reactions with human fibrinogen are only half of what would be expected if the first and second FPA were...
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