Article
Clusters of basic amino acids in midkine: roles in neurite-promoting activity and plasminogen activator-enhancing activity.
Journal of biochemistry - 1 Jun 1998
Akhter S, Ichihara-Tanaka K, Kojima S, Muramatsu H, Inui T, Kimura T, Kaneda N, Talukder A H, Kadomatsu K, Inagaki F, Muramatsu T
Abstract excerpt
The removal of N-terminally located clusters of basic amino acids (N-tail) or C-terminally located clusters of basic amino acids (C-tail) from the midkine (MK) molecule severely reduced its neurite-promoting activity. However, experiments involving chemically synthesized MK derivatives revealed that the roles of the N-tail and C-tail were mostly indirect ones, i.e. they probably maintain the steric arrangements...
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