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Article

The molecular environment of the Na+ binding site of thrombin.

Biophysical chemistry - 31 Jan 1997

Zhang E, Tulinsky A

Abstract excerpt

When Na+ binds to thrombin, a conformational change is induced that renders the enzyme kinetically faster and more specific in the activation of fibrinogen. Two Na+ binding sites have here been identified crystallographically by exchanging Na+ with Rb+. One is intermolecular, found on the surface between two symmetry-related thrombin molecules. Since it is not present in thrombin crystal structures having...

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PMID: 9108691
DOI: 10.1016/s0301-4622(96)02227-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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