Carboxyl-terminal truncation of recombinant factor XIII A-chains. Characterization of minimum structural requirement for transglutaminase activity.

Article

Carboxyl-terminal truncation of recombinant factor XIII A-chains. Characterization of minimum structural requirement for transglutaminase activity.

The Journal of biological chemistry - 7 Oct 1994

Lai T S, Achyuthan K E, Santiago M A, Greenberg G S

Abstract excerpt

A series of truncation mutants lacking 218, 229, 250, and 269 amino acid residues from the carboxyl terminus of blood coagulation factor XIII A-chains (FXIII A), designated as delta K513, delta A502, delta Y481, and delta K462, respectively, were expressed in Escherichia coli to define the minimu...

Topics

Base Sequence
Binding Sites
Fibrin
Molecular Sequence Data
Mutation
Recombinant Proteins
Structure-Activity Relationship
Transglutaminases

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