Article
Mechanism of the Ca2+-induced enhancement of the intrinsic factor VIIa activity.
The Journal of biological chemistry - 19 Sept 2008
Bjelke Jais R, Olsen Ole H, Fodje Michel, Svensson L Anders, Bang Susanne, Bolt Gert, Kragelund Birthe B, Persson Egon
Abstract excerpt
The intrinsic activity of coagulation factor VIIa (FVIIa) is dependent on Ca(2+) binding to a loop (residues 210-220) in the protease domain. Structural analysis revealed that Ca(2+) may enhance the activity by attenuating electrostatic repulsion of Glu(296) and/or by facilitating interactions between the loop and Lys(161) in the N-terminal tail. In support of the first mechanism, the mutations E296V and D212N...
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