Real-time measurement of lysis of mural platelet deposits by fibrinolytic agents under arterial flow.

doi:10.1114/1.46

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Article

Real-time measurement of lysis of mural platelet deposits by fibrinolytic agents under arterial flow.

Annals of biomedical engineering - 1 Jan 2000

Graham D A, Huang T C, Keyt B A, Alevriadou B R

Abstract excerpt

An in vitro whole blood reperfusion model was employed to quantify: (a) initial rates of lysis of mural platelet deposits from flowing blood onto fibrin-coated surfaces and (b) plasmin-mediated consumption of plasma plasminogen and fibrinogen, by recombinant tissue-type plasminogen activator (rt-...

Topics

Arteries
Biomedical Engineering
Blood Platelets
Drug Evaluation, Preclinical
Fibrinolysis
Fibrinolytic Agents
Genetic Variation
Hemodynamics
Hemostasis
Humans
In Vitro Techniques
Perfusion
Platelet Adhesiveness
Recombinant Proteins
Safety
Thrombosis
Tissue Plasminogen Activator

Source

Open in PubMed

Identifiers

PMID: 9662163
DOI: 10.1114/1.46

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9662163-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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