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Article

Calcineurin-GATA-6 pathway is involved in smooth muscle-specific transcription.

The Journal of cell biology - 18 Mar 2002

Wada Hiromichi, Hasegawa Koji, Morimoto Tatsuya, Kakita Tsuyoshi, Yanazume Tetsuhiko, Abe Mitsuru, Sasayama Shigetake

Abstract excerpt

Intracellular calcium is one of the important signals that initiates the myogenic program. The calcium-activated phosphatase calcineurin is necessary for the nuclear import of the nuclear factor of activated T cell (NFAT) family members, which interact with zinc finger GATA transcription factors. Whereas GATA-6 plays a role in the maintenance of the differentiated phenotype in vascular smooth muscle cells...

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Source

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Identifiers

PMID: 11889139
DOI: 10.1083/jcb.200106057
PMCID: PMC2173472

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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