Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis

23 Mar 2006

Abstract excerpt

GATA transcription factors play critical roles in restricting cell lineage differentiation during development. Here, we show that conditional inactivation of GATA-6 in VSMCs results in perinatal mortality from a spectrum of cardiovascular defects, including interrupted aortic arch and persistent truncus arteriosus. Inactivation of GATA-6 in neural crest recapitulates these abnormalities, demonstrating a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital heart defects research
Share to Coronary Artery Anomalies
Share to Mechanisms of cancer metastasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16557299
DOI: 10.1172/jci27363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesisPMID 16557299Read ↗

<i>GATA6</i> mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signalingSemantic proximity Read ↗

A threshold of GATA4 and GATA6 expression is required for cardiovascular development.Semantic proximity Read ↗

From embryogenesis to adulthood: Critical role for GATA factors in heart development and functionSemantic proximity Read ↗

Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve.Semantic proximity Read ↗

GATA-6 can act as a positive or negative regulator of smooth muscle-specific gene expression.Semantic proximity Read ↗

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.Semantic proximity Read ↗

GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesisSemantic proximity Read ↗

GATA6 Regulates Aortic Valve Remodeling, and Its Haploinsufficiency Leads to Right-Left Type Bicuspid Aortic Valve.Semantic proximity Read ↗

Gata4 and Gata5 Cooperatively Regulate Cardiac Myocyte Proliferation in MiceSemantic proximity Read ↗

Neural crest and cardiovascular development: a 20-year perspective.Semantic proximity Read ↗

Requirement of myocardin-related transcription factor-B for remodeling of branchial arch arteries and smooth muscle differentiation.Semantic proximity Read ↗

Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.