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Article

Dysregulation of E-cadherin by oncogenic Ras in intestinal epithelial cells is blocked by inhibiting MAP kinase.

American journal of surgery - 1 Nov 2003

Schmidt Carl R, Washington M Kay, Gi Y J, Coffey Robert J, Beauchamp R Daniel, Pearson A Scott

Abstract excerpt

BACKGROUND: Mutations in oncogenic Ras contribute to colorectal tumorigenesis. Loss of the cell adhesion protein E-cadherin is associated with tumor invasion and metastasis. METHODS: Expression of oncogenic Ras was induced in intestinal epithelial cells. Changes in cell morphology, E-cadherin protein expression, and E-cadherin localization were examined by light microscopy, Western blot, and immunofluorescence...

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Identifiers

PMID: 14599601
DOI: 10.1016/j.amjsurg.2003.07.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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