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Article

JunD regulates transcription of the tissue inhibitor of metalloproteinases-1 and interleukin-6 genes in activated hepatic stellate cells.

The Journal of biological chemistry - 29 Jun 2001

Smart D E, Vincent K J, Arthur M J, Eickelberg O, Castellazzi M, Mann J, Mann D A

Abstract excerpt

Activation of hepatic stellate cells (HSCs) to a myofibroblast-like phenotype is the pivotal event in hepatic wound healing and fibrosis. Rat HSCs activated in vitro express JunD, Fra2, and FosB as the predominant AP-1 DNA-binding proteins, and all three associate with an AP-1 sequence that is essential for activity of the tissue inhibitor of metalloproteinases-1 (TIMP-1) promoter. In this study, we used...

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Identifiers

PMID: 11337499
DOI: 10.1074/jbc.M101840200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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JunD regulates transcription of the tissue inhibitor of metalloproteinases-1 and interleukin-6 genes in activated hepatic stellate cells.PMID 11337499Read ↗

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Translational regulation of the JunD messenger RNA.Semantic proximity Read ↗

Basal Expression of IκBα Is Controlled by the Mammalian Transcriptional Repressor RBP-J (CBF1) and Its Activator Notch1Semantic proximity Read ↗

Control of the tissue inhibitor of metalloproteinases-1 promoter in culture-activated rat hepatic stellate cells: regulation by activator protein-1 DNA binding proteins.Semantic proximity Read ↗

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Targeted disruption of the murine junD gene results in multiple defects in male reproductive function.Semantic proximity Read ↗

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