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Article

Activation of the Murine Interleukin-12 p40 Promoter by Functional Interactions between NFAT and ICSBP

1 Oct 2003

Abstract excerpt

Interleukin (IL)-12 is a heterodimeric cytokine that is critical for the development of a T-helper-1 immune response and immunity against intracellular pathogens. The IL-12 p40 gene product, expressed specifically in macrophages and dendritic cells, heterodimerizes with p35 to form bioactive IL-12, and heterodimerizes with p19 to comprise the cytokine IL-23. Regulation of the murine IL-12 p40 promoter is complex....

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Identifiers

PMID: 12876285
DOI: 10.1074/jbc.m306441200

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