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Induction of NFATc2 Expression by Interleukin 6 Promotes T Helper Type 2 Differentiation

1 Jul 2002

Abstract excerpt

Interleukin (IL)-6 is produced by professional antigen-presenting cells (APCs) such as B cells, macrophages, and dendritic cells. It has been previously shown that APC-derived IL-6 promotes the differentiation of naive CD4+ T cells into effector T helper type 2 (Th2) cells. Here, we have studied the molecular mechanism for IL-6-mediated Th2 differentiation. During the activation of CD4+ T cells, IL-6 induces the...

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PMID: 12093869
DOI: 10.1084/jem.20020026

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