Article
Phosphorylation of the Bovine Papillomavirus E2 Protein on Tyrosine Regulates Its Transcription and Replication Functions.
Journal of virology - 15 Jan 2017
Culleton Sara P, Kanginakudru Sriramana, DeSmet Marsha, Gilson Timra, Xie Fang, Wu Shwu-Yuan, Chiang Cheng-Ming, Qi Guihong, Wang Mu, Androphy Elliot J
Abstract excerpt
Papillomaviruses are small, double-stranded DNA viruses that encode the E2 protein, which controls transcription, replication, and genome maintenance in infected cells. Posttranslational modifications (PTMs) affecting E2 function and stability have been demonstrated for multiple types of papillomaviruses. Here we describe the first phosphorylation event involving a conserved tyrosine (Y) in the bovine...
Topics
- Alphapapillomavirus
- Animals
- Bovine papillomavirus 1
- Cattle
- DNA-Binding Proteins
- Gene Expression Regulation, Viral
- Genome, Viral
- Humans
- Models, Molecular
- Mutation
- Phosphorylation
- Plasmids
- Protein Conformation