Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.

Nature cell biology - 1 Jun 2000

Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F

Abstract excerpt

Interleukin-1 (IL-1) is a proinflammatory cytokine that elicits its pleiotropic effects through activation of the transcription factors NF-kappaB and AP-1. Binding of IL-1 to its receptor results in rapid assembly of a membrane-proximal signalling complex that consists of two different receptor chains (IL-1Rs), IL-1RI and IL-1RAcP, the adaptor protein MyD88, the serine/threonine kinase IRAK and a new protein,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Differentiation
Share to Interleukin-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-1 Receptor-Associated Kinases

Share to JNK Mitogen-Activated Protein Kinases

Share to Myeloid Differentiation Factor 88

Share to Phosphoprotein Phosphatases

Share to Receptors, Immunologic

Share to Receptors, Interleukin-1

Source

Identifiers

PMID: 10854325
DOI: 10.1038/35014038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.PMID 10854325Read ↗

TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling.Semantic proximity Read ↗

The Interleukin-1 Receptor/Toll-Like Receptor Superfamily: Signal Transduction During Inflammation and Host DefenseSemantic proximity Read ↗

The Interleukin-1 Receptor/Toll-Like Receptor Superfamily: Signal Transduction During Inflammation and Host DefenseSemantic proximity Read ↗

TIRAP: an adapter molecule in the Toll signaling pathway.Semantic proximity Read ↗

Toll-Like Receptor Signaling Pathways—Therapeutic OpportunitiesSemantic proximity Read ↗

Immunobiology of Toll‐like receptors: Emerging trendsSemantic proximity Read ↗

Toll receptors: an expanding role in our understanding of human diseaseSemantic proximity Read ↗

Signalling, sorting and scaffolding adaptors for Toll-like receptorsSemantic proximity Read ↗

Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway.Semantic proximity Read ↗

Toll-like receptor signal transductionSemantic proximity Read ↗

Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production.Semantic proximity Read ↗

IRAK1 Serves as a Novel Regulator Essential for Lipopolysaccharide-induced Interleukin-10 Gene ExpressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.