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Article

Essential stations in the intracellular pathway of cytotoxic bovine seminal ribonuclease.

The Biochemical journal - 15 Mar 2002

Bracale Aurora, Spalletti-Cernia Daniela, Mastronicola Mariarosaria, Castaldi Francesco, Mannucci Roberta, Nitsch Lucio, D'Alessio Giuseppe

Abstract excerpt

Bovine seminal RNase (BS-RNase) is a dimeric RNase selectively cytotoxic for malignant cells. No information is available on its pathway from the extracellular matrix through the cytosol, where it degrades rRNA. An investigation of this pathway is reported here, carried out by immunofluorescence studies, by assessing the effects on BS-RNase cytotoxicity of drugs that affect specific intracellular compartments and...

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Identifiers

PMID: 11879181
DOI: 10.1042/0264-6021:3620553
PMCID: PMC1222418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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