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Article

Cytotoxic Activity of LLO Y406A Is Targeted to the Plasma Membrane of Cancer Urothelial Cells.

International journal of molecular sciences - 24 Mar 2021

Resnik Nataša, Tratnjek Larisa, Kreft Mateja Erdani, Kisovec Matic, Aden Saša, Bedina Zavec Apolonija, Anderluh Gregor, Podobnik Marjetka, Veranič Peter

Abstract excerpt

Identification of novel agents for bladder cancer treatment is highly desirable due to the high incidence of tumor recurrence and the risk of progression to muscle-invasive disease. The key feature of the cholesterol-dependent toxin listeriolysin O mutant (LLO Y406A) is its preferential activity at pH 5.7, which could be exploited either directly for selective targeting of cancer cells or the release of...

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Identifiers

PMID: 33805017
DOI: 10.3390/ijms22073305
PMCID: PMC8037347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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