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Article

Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.

Nature medicine - 1 Mar 2002

LeBlanc Heidi, Lawrence David, Varfolomeev Eugene, Totpal Klara, Morlan John, Schow Peter, Fong Sharon, Schwall Ralph, Sinicropi Dominick, Ashkenazi Avi

Abstract excerpt

The importance of Bax for induction of tumor apoptosis through death receptors remains unclear. Here we show that Bax can be essential for death receptor--mediated apoptosis in cancer cells. Bax-deficient human colon carcinoma cells were resistant to death-receptor ligands, whereas Bax-expressing sister clones were sensitive. Bax was dispensable for apical death-receptor signaling events including caspase-8...

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Identifiers

PMID: 11875499
DOI: 10.1038/nm0302-274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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