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Impact of p53 status on TRAIL-mediated apoptotic and non-apoptotic signaling in cancer cells

4 Apr 2019

Abstract excerpt

Due to their ability to preferentially induce cell death in tumor cells, while sparing healthy cells, TNF-related apoptosis-inducing ligand (TRAIL) and agonistic anti-TRAIL-R1 or anti-TRAIL-R2-specific antibodies are under clinical investigations for cancer-treatment. However, TRAIL-Rs may also induce signaling pathways, which result in malignant progression. TRAIL receptors are transcriptionally upregulated via...

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PMID: 30947287
DOI: 10.1371/journal.pone.0214847

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