Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Requirement of BAX for efficient adenovirus-induced apoptosis.

Journal of virology - 1 Nov 2002

Lomonosova Elena, Subramanian T, Chinnadurai G

Abstract excerpt

Infection of human epithelial cells with adenoviruses induces an apoptosis paradigm that is efficiently suppressed by the expression of viral E1B-19K protein, which is a functional homolog of the cellular antiapoptosis protein BCL-2. The mechanisms of adenovirus (Ad)-induced apoptosis appear to involve the cellular BCL-2 family proapoptotic proteins. Recent genetic studies with fibroblasts derived from mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviruses, Human
Share to bcl-2-Associated X Protein
Share to Blotting, Western

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Membrane

Share to Precipitin Tests

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins c-bcl-2

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 12388688
DOI: 10.1128/jvi.76.22.11283-11290.2002
PMCID: PMC136755

Genes

BAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement of BAX for efficient adenovirus-induced apoptosis.PMID 12388688Read ↗

Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak.Semantic proximity Read ↗

Evidence for involvement of BH3-only proapoptotic members in adenovirus-induced apoptosis.Semantic proximity Read ↗

Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cellsSemantic proximity Read ↗

Pro-apoptotic activity of transiently expressed BCL-2 occurs independent of BAX and BAK.Semantic proximity Read ↗

Role of BAX in the apoptotic response to anticancer agents.Semantic proximity Read ↗

Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.Semantic proximity Read ↗

Induction of Apoptosis by Human Nbk/Bik, a BH3-Containing Protein That Interacts with E1B 19KSemantic proximity Read ↗

Hematopoietic malignancies demonstrate loss-of-function mutations of BAX.Semantic proximity Read ↗

Bak functionally complements for loss of Bax during p14ARF-induced mitochondrial apoptosis in human cancer cellsSemantic proximity Read ↗

Vesicular Stomatitis Virus Induces Apoptosis Primarily through Bak Rather than Bax by Inactivating Mcl-1 and Bcl-X LSemantic proximity Read ↗

Loss of the proteins Bak and Bax prevents apoptosis mediated by histone deacetylase inhibitorsSemantic proximity Read ↗

Role of Bax in resveratrol-induced apoptosis of colorectal carcinoma cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.