Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of BAX in the apoptotic response to anticancer agents.

Science (New York, N.Y.) - 3 Nov 2000

Zhang L, Yu J, Park B H, Kinzler K W, Vogelstein B

Abstract excerpt

To assess the role of BAX in drug-induced apoptosis in human colorectal cancer cells, we generated cells that lack functional BAX genes. Such cells were partially resistant to the apoptotic effects of the chemotherapeutic agent 5-fluorouracil, but apoptosis was not abolished. In contrast, the absence of BAX completely abolished the apoptotic response to the chemopreventive agent sulindac and other nonsteroidal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Inflammatory Agents, Non-Steroidal
Share to Anticarcinogenic Agents
Share to Antimetabolites, Antineoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to bcl-2-Associated X Protein

Share to bcl-X Protein

Share to Indomethacin

Share to Intracellular Membranes

Share to Proto-Oncogenes

Source

Identifiers

PMID: 11062132
DOI: 10.1126/science.290.5493.989

Genes

BAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of BAX in the apoptotic response to anticancer agents.PMID 11062132Read ↗

Role of Bax in resveratrol-induced apoptosis of colorectal carcinoma cells.Semantic proximity Read ↗

Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak.Semantic proximity Read ↗

Resistance of colon cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl-2 and Bcl-X(L) in addition to Bax and p53 status.Semantic proximity Read ↗

Requirement of BAX for efficient adenovirus-induced apoptosis.Semantic proximity Read ↗

Significance of Increased Apoptosis and Bax Expression in Human Small Intestinal AdenocarcinomaSemantic proximity Read ↗

Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.Semantic proximity Read ↗

Hematopoietic malignancies demonstrate loss-of-function mutations of BAX.Semantic proximity Read ↗

Inhibition of the NF-kappa B transcription factor increases Bax expression in cancer cell lines.Semantic proximity Read ↗

Bcl-xL is an oncogenic driver in colorectal cancer.Semantic proximity Read ↗

Anti-cancer Effects of JKA97 Are Associated with Its Induction of Cell Apoptosis via a Bax-dependent and p53-independent PathwaySemantic proximity Read ↗

Loss of the proteins Bak and Bax prevents apoptosis mediated by histone deacetylase inhibitorsSemantic proximity Read ↗

Regulation of Bax Activation and Apoptotic Response to Microtubule-damaging Agents by p53 Transcription-dependent and -independent PathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.