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Article

Downregulation of active caspase 8 as a mechanism of acquired TRAIL resistance in mismatch repair-proficient colon carcinoma cell lines.

International journal of oncology - 1 Oct 2010

Van Geelen Caroline M M, Pennarun Bodvael, Ek Wytske Boerma-Van, Le Phuong T K, Spierings Diana C J, De Vries Elisabeth G E, De Jong Steven

Abstract excerpt

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers the apoptotic cascade in various colon cancer cell lines after binding to the membrane receptors DR4 and DR5. However, not all cancer cell lines are sensitive to the therapeutic recombinant human TRAIL (rhTRAIL). To investig...

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Identifiers

PMID: 20811726
DOI: 10.3892/ijo_00000755

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20811726-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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