Article
Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer.
Carcinogenesis - 1 Jul 2012
Gilsing Anne M J, Berndt Sonja I, Ruder Elizabeth H, Graubard Barry I, Ferrucci Leah M, Burdett Laura, Weissfeld Joel L, Cross Amanda J, Sinha Rashmi
Abstract excerpt
Meat mutagens, including heterocyclic amines (HCAs), polycyclic aromatic hydrocarbons (PAHs) and N-nitroso compounds (NOCs), may be involved in colorectal carcinogenesis depending on their activation or detoxification by phase I and II xenobiotic metabolizing enzymes (XME). Using unconditional logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI), we examined the intake of five meat...
Topics
- Adenoma
- Aged
- Case-Control Studies
- Colorectal Neoplasms
- Female
- Humans
- Male
- Meat Products
- Middle Aged
- Mutagens
- Polymorphism, Single Nucleotide
- Xenobiotics