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Article

Meat-related mutagen exposure, xenobiotic metabolizing gene polymorphisms and the risk of advanced colorectal adenoma and cancer.

Carcinogenesis - 1 Jul 2012

Gilsing Anne M J, Berndt Sonja I, Ruder Elizabeth H, Graubard Barry I, Ferrucci Leah M, Burdett Laura, Weissfeld Joel L, Cross Amanda J, Sinha Rashmi

Abstract excerpt

Meat mutagens, including heterocyclic amines (HCAs), polycyclic aromatic hydrocarbons (PAHs) and N-nitroso compounds (NOCs), may be involved in colorectal carcinogenesis depending on their activation or detoxification by phase I and II xenobiotic metabolizing enzymes (XME). Using unconditional logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI), we examined the intake of five meat...

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Identifiers

PMID: 22552404
DOI: 10.1093/carcin/bgs158
PMCID: PMC3499048

Genes

NAT1
AHR
EPHX1
GSTM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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