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Article

Nucleotide modification at the gamma-phosphate leads to the improved fidelity of HIV-1 reverse transcriptase.

Nucleic acids research - 1 Jan 2005

Mulder Brent A, Anaya Steve, Yu Peilin, Lee Keun Woo, Nguyen Anvy, Murphy Jason, Willson Richard, Briggs James M, Gao Xiaolian, Hardin Susan H

Abstract excerpt

The mechanism by which HIV-1 reverse transcriptase (HIV-RT) discriminates between the correct and incorrect nucleotide is not clearly understood. Chemically modified nucleotides containing 1-aminonaphthalene-5-sulfonate (ANS) attached to their gamma-phosphate were synthesized and used to probe nucleotide selection by this error prone polymerase. Primer extension reactions provide direct evidence that the...

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Identifiers

PMID: 16141194
DOI: 10.1093/nar/gki779
PMCID: PMC1197130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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