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Article

Polymorphisms in the tumor necrosis factor-alpha gene promoter may predispose to severe silicosis in black South African miners.

American journal of respiratory and critical care medicine - 1 Mar 2002

Corbett Elizabeth L, Mozzato-Chamay Nadine, Butterworth Anthony E, De Cock Kevin M, Williams Brian G, Churchyard Gavin J, Conway David J

Abstract excerpt

Susceptibility to silicosis is in part genetically determined. Polymorphisms in the promoter region of tumor necrosis factor (TNF)-alpha, a cytokine with a central role in the pathophysiology of silicosis, have been associated with predisposition to several infectious and inflammatory diseases. Polymorphisms at positions -308, -238, and -376 in the TNF-alpha promoter region were compared in nine patients with...

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Source

Identifiers

PMID: 11874815
DOI: 10.1164/ajrccm.165.5.2010050

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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