Article
Polymorphisms in the promoter of the tumor necrosis factor-alpha gene in coal miners.
American journal of industrial medicine - 1 Oct 1998
Zhai R, Jetten M, Schins R P, Franssen H, Borm P J
Abstract excerpt
Tumor necrosis factor-alpha (TNF) is recognized as a central mediator of mineral dust-induced lung fibrosis, and genetic polymorphisms of the TNF promoter have been reported to influence levels of TNF production. To assess whether polymorphisms within the TNF promoter gene are associated with sus...
Topics
- Base Sequence
- Chi-Square Distribution
- Coal Mining
- Cohort Studies
- Confidence Intervals
- Confounding Factors, Epidemiologic
- Environmental Monitoring
- Enzyme-Linked Immunosorbent Assay
- Follow-Up Studies
- Gene Frequency
- Humans
- Male
- Middle Aged
- Multivariate Analysis
- Occupational Exposure
- Odds Ratio
- Phenotype
- Pneumoconiosis
