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Article

Polymorphisms of the IL-1 gene complex in coal miners with silicosis

1 Jan 2001

Abstract excerpt

BACKGROUND: Silicosis is characterized by fibrosing nodular lesions that eventually develop into progressive pulmonary fibrosis. Pro-inflammatory cytokines, such as interleukin-1 (IL-1), play a key role in the development of silicosis by regulating mediators which are responsible for lung injury, inflammation, and potentially fibrosis. To study whether functional single nucleotide polymorphisms (SNPs) located in...

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PMID: 11241561
DOI: 10.1002/1097-0274(200103)39:3<286::aid-ajim1016>3.0.co;2-7

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