Article
Genetic polymorphisms and their effects on the severity of silicosis in workers exposed to silica in Brazil.
Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia - 1 Jan 2022
Castro Marcos César Santos de, Nani Angela Santos Ferreira, Salum Kaio Cezar Rodrigues, Rolando Jônatas de Mendonça, Santos Júlia Fernandes Barbosa Dos, Castro Hermano Albuquerque de, Ribeiro Patrícia Canto, Costa Walter, Mello Cícero Brasileiro de, Kohlrausch Fabiana Barzotto
Abstract excerpt
OBJECTIVE: Silicosis is a pneumoconiosis characterized by fibrosis of the lung parenchyma caused by inhalation of silica particles. Genetic factors might play a role in the severity silicosis. We sought to evaluate the influence of polymorphisms in the ACE, FAS, FASLG, NOS2, IL1RN, FAM13A, TGFB1, and TNF genes on the severity of silicosis. METHODS: Nine polymorphisms were genotyped by PCR in a sample of 143...
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