Article
Antithetical effect of tumor necrosis factor-alphagene polymorphism on coal workers' pneumoconiosis (CWP).
American journal of industrial medicine - 1 Jul 2005
Wang Xin-Tao, Ohtsuka Yoshinori, Kimura Kiyonobu, Muroi Miho, Ishida Takashi, Saito Junpei, Munakata Mitsuru
Abstract excerpt
BACKGROUND: Inter-individual variation in the severity of pneumoconiosis has been described, even with the same environmental exposure. We hypothesized that TNF-alpha promoter polymorphisms associate with lung responses to environmental exposure in coal worker's pneumoconiosis (CWP) patients. METHODS: We examined polymorphisms at -238, -308, and -376 in 124 patients with CWP who had similar dust exposure history...
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