Article
Cytokine polymorphisms in silicosis and other pneumoconioses.
Molecular and cellular biochemistry - 1 Jan 2002
Yucesoy Berran, Vallyathan Val, Landsittel Douglas P, Simeonova Petia, Luster Michael I
Abstract excerpt
Silicosis and coal workers' pneumoconiosis are complex multifactorial lung diseases whose etiopathogenesis are not well defined. It is generally accepted that fibrotic lung disorders are mediated by macrophage-derived cytokines and growth factors. There is evidence showing a crucial role for tumor necrosis factor-a (TNF-alpha) and interleukin-1 (IL-1) in inflammation caused by silica dust and in the transition...
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