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Variations in insulin secretion in carriers of gene variants in IRS-1 and -2.

Diabetes - 1 Mar 2002

't Hart Leen M, Nijpels Giel, Dekker Jacqueline M, Maassen J Antonie, Heine Robert J, van Haeften Timon W

Abstract excerpt

Associations between type 2 diabetes (and/or parameters contributing to glucose homeostasis) and genetic variation in the genes encoding insulin receptor substrate (IRS)-1 and -2 have been reported in several populations. Recently, it has been reported that the Gly(972)Arg variant in IRS-1 was associated with reduced insulin secretion during hyperglycemic clamps in German subjects with normal glucose tolerance....

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Identifiers

PMID: 11872698
DOI: 10.2337/diabetes.51.3.884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Variations in insulin secretion in carriers of gene variants in IRS-1 and -2.PMID 11872698Read ↗

The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans.Semantic proximity Read ↗

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Prevalence of the insulin receptor substrate-1(IRS-1) Gly972Arg and the insulin receptor substrate-2(IRS-2) Gly1057Asp polymorphisms in PCOS patients and non-diabetic healthy women.Semantic proximity Read ↗

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