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Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphism.

Diabetes - 1 May 2002

Marchetti Piero, Lupi Roberto, Federici Massimo, Marselli Lorella, Masini Matilde, Boggi Ugo, Del Guerra Silvia, Patanè Giovanni, Piro Salvatore, Anello Marcello, Bergamini Ettore, Purrello Francesco, Lauro Renato, Mosca Franco, Sesti Giorgio, Del Prato Stefano

Abstract excerpt

Type 2 (non-insulin-dependent) diabetes results from decreased insulin action in peripheral target tissues (insulin resistance) and impaired pancreatic beta-cell function. These defects reflect both genetic components and environmental risk factors. Recently, the common Gly(972)-->Arg amino acid polymorphism of insulin receptor substrate 1 (Arg(972) IRS-1) has been associated with human type 2 diabetes. In this...

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Identifiers

PMID: 11978638
DOI: 10.2337/diabetes.51.5.1419

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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