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Article

Genotype/phenotype comparisons: a probe for the effect of disease progression on drug metabolism.

Current opinion in drug discovery & development - 1 Jan 2002

Williams Marion L, Wainer Irving W

Abstract excerpt

The effect of disease state on drug metabolism has been investigated using the relationship between genotype and metabolic phenotype. The two polymorphic probes, N-acetyltransferases-2 (NAT2) and cytochrome P450 2C19 (CYP2C19), were respectively used in HIV+/AIDS patients and patients with advanced cancer. The results of the studies suggest that advanced disease produces discordances between genotype and...

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Identifiers

PMID: 11865668

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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