Article
Prediction of metabolic activity from genotype: the gene-dose effect of N-acetyltransferase.
Therapeutic drug monitoring - 1 Feb 2001
Meisel P, Arndt D, Scheuch E, Klebingat K J, Siegmund W
Abstract excerpt
Metabolic activity of the polymorphic N-acetyltransferase (NAT2) is determined by the mutation pattern of the NAT2 gene. This results in interindividual differences in the metabolic capacity (the phenotype), with continuous distribution of the activities rather than qualitative distinction between rapid and slow acetylators. To determine whether the phenotype might be predicted solely from the mutation pattern of...
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