Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acetylator phenotype and genotype in HIV-infected patients with and without sulfonamide hypersensitivity.

Journal of clinical pharmacology - 1 Jun 2002

O'Neil William M, MacArthur Rodger D, Farrough Marti J, Doll Mark A, Fretland Adrian J, Hein David W, Crane Lawrence R, Svensson Craig K

Abstract excerpt

Adverse reactions to sulfonamides occur at a higher frequency in patients infected with the human immunodeficiency virus (HIV) than noninfected patients. Some studies have suggested that patients with the slow acetylator phenotype are predisposed to these reactions, whereas other studies suggest that the slow acetylator genotype is not a predisposing factor. To rationalize these seemingly contradictory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Hypersensitivity
Share to Acetylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Anti-Infective Agents

Share to Arylamine N-Acetyltransferase

Share to Genotype

Share to HIV Infections

Share to Phenotype

Share to Trimethoprim, Sulfamethoxazole Drug Combination

Source

Identifiers

PMID: 12043950
DOI: 10.1177/00970002042006004

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acetylator phenotype and genotype in HIV-infected patients with and without sulfonamide hypersensitivity.PMID 12043950Read ↗

Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity.Semantic proximity Read ↗

Acetylator phenotype prevalence in HIV-infected patients without previous trimethoprim-sulfamethoxazole hypersensitivity.Semantic proximity Read ↗

Acetylation phenotype and cutaneous hypersensitivity to trimethoprim-sulphamethoxazole in HIV-infected patients.Semantic proximity Read ↗

N-acetylation among HIV-positive patients and patients with AIDS: when is fast, fast and slow, slow?Semantic proximity Read ↗

Prominence of slow acetylator phenotype among patients with sulfonamide hypersensitivity reactions.Semantic proximity Read ↗

N-acetyltransferases: pharmacogenetics and clinical consequences of polymorphic drug metabolism.Semantic proximity Read ↗

Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity.Semantic proximity Read ↗

N-acetyltransferase 2 polymorphism in patients infected with human immunodeficiency virus.Semantic proximity Read ↗

A slow acetylator genotype is a risk factor for sulphonamide-induced toxic epidermal necrolysis and Stevens-Johnson syndrome.Semantic proximity Read ↗

Slow acetylator genotypes as a possible risk factor for infectious mononucleosis-like syndrome induced by salazosulfapyridine.Semantic proximity Read ↗

Acetylator phenotype and genotype in patients infected with HIV: discordance between methods for phenotype determination and genotype.Semantic proximity Read ↗

Acetylator status and tolerance of high-dose trimethoprim-sulfamethoxazole therapy among patients infected with human immunodeficiency virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.