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Chronic hypoxia compromises repair of DNA double-strand breaks to drive genetic instability

1 Jan 2012

Abstract excerpt

Hypoxic cells have been linked to genetic instability and tumor progression. However, little is known about the exact relationship between DNA repair and genetic instability in hypoxic cells. We therefore tested whether the sensing and repair of DNA double-strand breaks (DNA-dsbs) is altered in irradiated cells kept under continual oxic, hypoxic or anoxic conditions. Synchronized G0-G1 human fibroblasts were...

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PMID: 22266907
DOI: 10.1242/jcs.092262

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